Cellular and network mechanisms of genetically-determined absence seizures

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Cellular and network mechanisms of genetically-determined absence seizures.

The absence epilepsies are characterized by recurrent episodes of loss of consciousness associated with generalized spike-and-wave discharges, with an abrupt onset and offset, in the thalamocortical system. In the absence of detailed neurophysiological studies in humans, many of the concepts regarding the pathophysiological basis of absence seizures are based on studies in animal models. Each o...

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Epileptic seizures constitute a complex multiscale phenomenon that is characterized by synchronized hyperexcitation of neurons in neuronal networks. Recent progress in understanding pathological seizure dynamics provides crucial insights into underlying mechanisms and possible new avenues for the development of novel treatment modalities. Here we review some recent work that combines in vivo ex...

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Network Models of Absence Seizures

Absence epilepsy is a very common disorder in young children and consists of seizures that are characterizedby the sudden onset of w3 Hz large-amplitude oscillations in the electroencephalogram (EEG) (Figure 2.1). These generalized seizures terminate as suddenly as they appear, and brain activity almost immediately reverts back to normal activity. The typical pattern of the oscillation consists...

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A genetically determined condition?

Papadatos, C., Alexiou, D., Nicolopoulos, D., Mikropoulos, H., and Hadzigeorgiou, E. (1974). Archives of Disease in Childhood, 49, 927. Congenital hypoplasia of depressor anguli oris muscle: a genetically determined condition? The frequency of hypoplasia of the depressor anguli oris muscle was 37 cases among 4 530 consecutive births (8 -2 %). Diagnosis was based on clinical and electromyographi...

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ژورنال

عنوان ژورنال: Thalamus and Related Systems

سال: 2005

ISSN: 1472-9288,1744-8107

DOI: 10.1017/s1472928807000209